I am pretty sure it's not just the barrel that is replaced. I would never run even close to full house 10mm through any gun made for .45.
Maybe but the G21 is an exception. It would handle the 10mm high pressure. .45 Super works great with the G21.
To be picky, .45 super is neither as powerful or as high pressure as 10mm(30k psi vs 37.5). The G21 slide is quite a bit lighter than the G20. Which is where my comment about shooting 10mm in .45 guns came from. The frame is indeed identical.



























