My family, all my friends, and many customers shoot .300 weatherby rifles, also in Colt Sauer, same calibre, The best all around load, and I've done a lot of testing, a LOT, is a 180 grian bullet, here's why, Speer makes a hotcore, semi-roundnose, and it's good for the first one up because where I hunt the bears also hunt, and I've hand my brushes. Then you load 180 GrandSlam Speer hotcor's for max. expansion, without over expansion, as many bullets will go right through. I've shot many an elk even as close as 25 yards, and I don't get an exit, all energy delivered. Then I use a real long, 180 Boatail bullet for the log shots, and make sure it has soft lead core, or has a plastic tip to enhanse the expansion, thus more energy delivered, when the bullet slows down at 500 yards.
By doing this, your point of aim never changes, if you go light then heavy bullet, with a big recoil gun, your heavy bullets hit high in close, as they are slower exiting the barrel. And loads, yes I've done almost them all.
MRP is good, but due to availability, I now stick soly with H-4831, and load about 83 grains, it's warm, but you have to work up a load as every gun has different drag and pressure from the internal balistic point of view. Also load the bullet as long as you can, and still have it feed the clip, more accurage, as weatherby has a bit more freebore to keep pressures down.
Fed 215 primes are the best. You wouldn't beleive the work my gun has done, and never misses a beat!
SO, 180's all the way, the longer bullet is more accurate,
Don't use IMR 4831, you will oveload, and ruin brass, it's hotter, and has to go down to about 79 grains, or less. Also H-1000 powder is good, the fuller the case the better, and the safer, expecially if you are shooting down hill, the full case is a consistent burn every time.
Lots of tips here, hope they help.
Kurt