I'm not much for Glocks in 40S&W, but in 9MM they 'rock'!
Glocks in 40S&W have a history of KABOOM..you can search out the background on this here and other web sights.
The 35 comes with a longer sight radius, adjustable (plastic!) rear sight, extended slide/magazine releases, and the 3.5LB. trigger, all of which make it a nicer gun than the 22. The grip and frame are the same, so no advantage for your larger 'mitts'!
If you're not 'married' to 40S&W, I would strongly suggest the 9MM version, the Glock34. It has all of the advantages as noted, and comes in a calibre which is cheap to shoot, with less recoil.
The Glock 34 is, arguably, the best pistol made by Glock...although I am also partial to the smaller Glock 19, which is also one on my personal 'keepers'.
If you are intent on your calibre choice as 40S&W, I would strongly suggest that you have a close look at the Smith and Wesson M&P40. It is much superior to the Glock 22 in terms of adjustable grip, seems to be very accurate, and is 'softer' shooting...my personal choice in a 'plastic' 40S&W.