Personally, owning both a K100 and G22, I find I shoot them both equally well (or is that poorly...

). Both guns are around 1.5K round count so I cannot comment on the long term reliability.
The one thing I will give the K100 a higher grade on is the ergonomics. It just seems to fit my hands better.
I will echo the sentiment that as the K100 is new, there is a lack of aftermarket support (holsters, etc..).
BTW, I am sure those following the K100 reports from Omen (with my K100) on the odd F2F issue on the last round in rapid fire exercizes... I am happy to report that Marstar sent me another GP Mag to test (Kudo's to Marstar..

). I also now have 8 more CZ modified mags of assorted mfg(OEM, Promag,etc).
So, anytime you want to beat up on my K100 again Omen, let me know...
I will also state it is very refreshing to have access to the MFG on this board for the Gun....That level of commitment and access speaks volumes for me..
If anyone gets out to MCO, give me a PM and will let you give it a try.
Regards, Brent