I have used IMR4227, H110, Unique, 2400, Blue Dot and Lil Gun. I always go back to Lil Gun for the max power hunting loads and Blue Dot for the medium stuff. Lil Gun give highest velocities with the heavier bullets and less pressure than H110. Blue Dot gives respectable velocities with moderate ( economical) powder charges. Neither of my go to powders require magnum primers either. I would use Unique or 2400 in place of Blue Dot but they are unobtanium and I have lots of BD on hand. I don't think you said what rifle you have but there are definite strength differences in the actions. The model 92 (clones) being the strongest, Marlin 1894 next and Winchester Model 94 the weakest.