Geez, when did a .30-06 with a 150gr bullet become a less than desirable choice for deer hunting? Pick a good hunting bullet, load it to a MV of 2800fps and you are golden. A gazzilion dead deer can't be wrong on this. Personally I like a 165gr bullet in the .30-06, but there is nothing wrong with a 150. I've shot deer with all of a .25-06, .270,.280, 7x57, .30-30, .308, .30-06, .303, .348 Win, .44-40, and a .50 cal muzzle loader at ranges from 10-300yds and they all pretty much fell down the same, except for the .44-40 and .50 cal muzzle loader where they leaked to death due to the absence of high velocity shock effect.
My personal preference for deer is a 7x57 Mauser with a 140gr bullet at a MV of 2800fps, but this takes nothing away from a .30-06 with a 150/165gr. For elk or moose go to a 180gr. When loading for a .30-06 with 150/165 gr bullets try IMR4064 or IMR4895. Velocity is a bit less than from slower burning propellants, but accuracy tends to be excellent.
If you are concerned about bullets being too destructive on meat at close ranges, try a milder load with less MV. I used to hunt deer in the heavy timber in NB where shot opportunities often came at very close ranges. I loaded my .303 with 180gr bullets on the slow side for this.