45/70 for grizzlies
if it were my choice, 45/70 all the way, i have some nasty powerful loads for a marlin rifle if your into handloading 350 grain round nose bullets, i shoot these in my handi rifle, and i get ex 3" groups at 150yrds, and power level is about 80-85% of a 458 win magnum, let me know if you have a marlin gun, of recent manufacture, these loads will work perfect in it, recoil is a bit tough, but, it means business
as far as 300 hh, no issues with the caliber, its bullet construction that worries me when i comes to big critters such as a grizzly, you need a bullet that retains energy and bullet mass, to work well in 30 cal guns, only really good bullet i would suggest for a grizzly out of a 30 cal would be the hornady 220grn round nose, pushed at approx 2400-2600 fps, that would give sufficient thump, to get rid of mr bear, however your range is cut down drastically with that bullet, max effective range i feel would be 150-200yrds at most,in any 30 cal, though the 45 is slow in speed, it hits like a tonne of bricks, i use the hornady 350 round nose for big things in my 45, also have used 400gr speers, but their jacket is thin and not suitable for grizzlies, i have some 550 gr hard cast lead slugs im working on with loads, ill keep you posted