Bone-collector,
I'm an Alberta resident and I have never had a problem getting my BC assistant-guide license. I know several Albertans that head to BC for work every year, so non-residents are fine. The outfitter has different restrictions, but I'm not sure on these.
As for being a tough job on the family, it really all depends on where you live, what type of lifestyle you're used to, and where you decide to guide. Some bush-guiding you can be gone for up to 6-8 weeks and possibly never get flown out to town. Some camps you'll be out after every hunt for a day or two. It really all depends. In Alberta doing whitetail hunts you may be at the hotel every night enjoying a fine meal, satellite tv, and all the joys of being at home....