I recall a post here or on another forum about a mysterious excessive pressure case. Forget all the details, but the thread went on and on with all kinds of the usual suggestions as to what it was. The OP even sent cartridges back to the powder manufacture for analysis, but the problem was there were some that had high pressure and some that didn't. The thread went dead, and weeks, months, or perhaps even a year later, the OP came back and admitted what happened. He was loading a fast powder like pistol and dumped the remaining fast powder from the measure back into the original container of rifle powder, and as a result ended up with two canisters of powder, one of which was contaminated with some very fast powder, and the other one good. The contaminated powder was erratic and produced high pressure, as one might expect.
I took it as a reminder to always be super careful about getting powders mixed up.