A friend of mine whom I reload for had a failure with the 06, 165 gr Nosler BTs, at 2900 fps, hit a mule deer back bone, knocked it down, but by the time he got to it (down one slope and up another on the other side of a small valley), it bounced up and took off. We use Barnes X bullets (150 gr) now. Not as fast as the BTs, but oddly enough, more accurate in this particular rifle (Win 70 Ranger). Personally, I don't usually hunt with one (boring), but I own 4 or so and have tried them all out, with no real issues on any game I would use an 06 on. FWIW - dan