i own and have hunted with all 3 of the options you are considering.
22-250 pros. fast flat and anchors things hard! cons. on smaller game fast varmint bullets run the risk of making a mess.
223. pros. cheap to shoot, lots of ammo, good on fur. cons. more bullet drop for long range shooting
204. pros. fast and flat like the 22-250, great on fur. cons. less factory ammo and on longer shots bullet placement is key in anchoring the animal solidly.
unless you plan to reload i would suggest the 223. even though it is kind of a vanilla cartridge it checks off all the right boxes for what you are looking for.
Predator hunting is not high volume shooting. If the difference between 223 and any other centerfire is applicable, price wise, perhaps you could try something else.
If pelts are a consideration, projectile is more important than caliber. A rather stout bullet, not a explosive gopher/varmit bomb. A smallish deer rifle is fine, with your deer load.




























