I first determine the maximum working load through 1 gr increments starting at least 5 grs below the anticipated maximum load. I fire each round over a chronograph and watch for a number of pressure signs. As a rule, when the book velocity has been reached, you are at the maximum pressure, which is a rule of thumb that will keep you safe provided you have a number of sources that agree with the components you have chosen.
But first lets discuss pressure signs. As a rule watching primer and brass for pressure signs tends to be unrealiable as some brass is harder than others, and there are variations in primer pocket and, flash-hole sizes, and in primer cup hardness. All the same, if you see an extractor mark which appears as a shiny spot on the case head, you should consider that as a high pressure warning. If you measure the web of the case and discover .001" of expansion, that should be considered a warning sign of high pressure. If you experience a sticky or difficult bolt lift, that is an outright danger sign. If you have a chronograph, any reading higher than book velocity should be taken as a warning, but not all chronographs a re equal, and velocities can also be affected by temperature and barometric pressure. If you have a few factory rounds, it doesn't hurt to use them as a control for your chronograph.
Once I have determined the maximum load, that is the load that shows the earliest signs of pressure, I drop one full grain and determine that to be my maximum working load with those components. Be aware that there can be significant variation in case capacity amongst manufacturers so what is a maximum load in one case might be a bit light or a high pressure in another.
If I intend to tweak this load for accuracy, everything I do from this point on reduces pressure. One difference here is that of the seating depth of my bullet. In a hunting or field load, I want the ammo to feed reliably from the magazine, so I tend to choose bullets with a crimping groove or a cannelure and crimp each round, as crimping tends to uniform the bullet pull weight in a similar fashion to seating the bullet into the lands. When I'm attempting to gain the maximum accuracy, OAL is less important so I begin with the bullet seated out enough to firmly contact the lands. Once I have determined the optimum powder charge, I then experiment with small jumps to the lands which normally reduces pressure in bottle neck cases, but can increase pressure in straight wall cartridges due to the reduced powder capacity.
When I tweak the load for accuracy, I work away from the maximum load in one grain increments. If accuracy improves after the first reduction of one grain, I drop another. If accuracy drops off I go back up a half grain , then by a quarter grain. I don't attempt to adjust finer than a quarter grain because I don't believe that loading scales are accurate enough to uniformly measure differences smaller than a quarter grain.