Hmmmmm. You kind of opened up a can of worms with this one.... I have personally witnessed a 22-250, shooting 50gr vmax and 55gr nosler varmageddons drop coyotes consistently out to 500 yards and a hand full past that. (Ranged spots multiple times, these are legit). Same with the 243 and 220 swift, easily 300, 500 still drops them. The 204 is different, although having ultra high BCs, a buddy and I were testing some 35gr beegers loaded as fast as we could to maintain accuracy, and at a milk jug at 600 yards, it was penetrating and not expanding at all (that bullet should vapourize after hitting it). Although I only shot a couple with my 204 and they were all close (under 200 yards), a good load worked for 35gr Berger, 39gr sbks or 40gr vmax should easily drop them out to 300 yards or less. Although everyone screams "extremely fur friendly", I have yet to see it. But this fall I'll really give the 204 a run for its money and see!