Many years ago I took one small-medium grizzly with my Winchester 1886 and a Speer 400 gr flat point at 1600 Fps, range est 125 yards. Bear was standing on hind legs looking at me, more curious than aggresive, a centre chest hit did not exit. The bear dropped, turned and ran, probably went 200+ yards, fortunately not towards me. One shot kill, yes, fight stopper, no. Took moose with the same load, usually one shot, always under 175 yards, also two with 486gr hard cast lead bullet, these have great penetration, very little expansion, in effect a solid. The Hornady 350 gr round nose bullets I tried were designed for the 458 Win mag, jackets too heavy for most sane 45-70 velocities although I shot one moose and one black bear with these bullets in a .458x2" at about 2050 fps with great one shot kills. Also worked great in a long throated Ruger #1 45/70 at a chronographed 2400 fps. Speer makes (or did) a good 350 gr semi spitzer flat point with a medium jacket and Nosler has their ever reliable Partition. Bullets are made differently for for the 45/70 than the ones for the .458 mag and they are not interchangeable for reliable use on game, especially potentially dangerous game. The same goes for hard or soft cast bullets. Match your bullet to your game and your velocity. Good luck. J.