I beg to differ, the 2506 was made in the 1930's, brass and ammo are still readily available for all 3 of these calibers. If anything is a passing fad it is these short action magnums that do the same job as there long action counter oparts with a similar bullet weight and powder charge. The only gain with these is negated if the manufacturers dont make a shorter stiffer(more acurate) action to suit these rounds.
With the exception of the 6.506 which is not yet a sammi standard the rest of those calibers are readily available and regular ammo can be fired in any of the Ackley chamberings. I had a 3006 AI and was quite satisfied with is, currently own a 2506 and would chamer it to AI if I had a reamer available. The 6.5 06 is a very ineresting chamer and the AI would only be better.
There is no such thing as a do all end all rifle, the 3006 is the closest you will get but does not do all of the jobs intended with the same zing as some of the custom chamberings, so if you want to fill a certain niche and are willing to experiment, more power to you, you will get a great deal of satisfaction out of playing with these rounds and have something the non reloading regular hunters could never dream of.
Also if people did not have a desire to experiment and try new and different things we would still be shooting lead bullets from front stuffing guns.
As far as pro's and cons, AI chamerings provide around 3-7% increase in velocity, reduced bolt thrust, and eliminate the need to trim in most cases. Reguler rounds may be fired in Ackley chambers and some of your best shooting will be groups fired while fireforming these cases. The 6.5 bullet is usually carries a high bc and is good to long ranges. Slight to severe reduction in barrel life to due increase powder consumption is one of the cons, the second in my opinion is the need to buy a reamer if you can't find a smith that has one.
Andy