In a word, no, one of the all time classics!
best all around rifle I've used, moose or deer, the old saying, which doesn't apply to many cartridges was,"eat right up to the hole".
shoot 'em through the lungs, and be quiet, no hootin' and hollering (that's what gets moose moving fast to somewhere else, not the shot). Deer are spooky to begin with so normally leave when shot.
Only, moose I've seen trying to run off, personal experience or watching dvds, are the ones that 'bonehead' starts celebrating, or a partner or guide yells to him to 'hit 'em again!!!!'.
The only thing about it is the weight of the gun, if that's not an issue, you're making a great choice.
I handloaded mine with 300 grain Sierra spitzer and used IMR 3031, don't have the load data in front of me, so not going to guess.
TB