It is as accurate as you can hold it, once you know where the sights are pointed. It will not be as accurate in your hand as an adjustable sighted target specific pistol. The sights on a gun have little to do with the accuracy of a firearm, but they have a lot to do with what you can do with available accuracy of the gun. Once you have adjustable sights dialed in for the load you are using, they might as well be fixed because you don't change them, unless you use different ammunition and the gun is shooting to a different point . Also target specific guns have sights that give a better, clearer and more defined sight picture that can be repeated, the fixed sights on a Vaquero are good for that type of gun but it will not give as good a sight picture as a target specific gun. I can plink cans offhand ,out to 25 yards with fixed sights with a .45 Uberti single action, but I can't hit the can everytime , but then I can't hit the can everytime with my target sighted Ruger .22 pistol. Shooting a hand gun is not easy out at .25 yards, if it was easy there would be no fun doing it, hey, anyone could do it. Back to your question, if you want to plink at targets and have fun at the range ,then the Vaquero is a good gun, if you want to shoot in some kind of interclub competition or train for the olympics ,then some thing along the lines of a Ruger MK1 or 2 or 3 with heavy barrel and adjustable sights would be a better way to start. Different guns have different purposes.