I've used Titegroup in my .45ACP and of the powders I have tried (W231, Bullseye, Red Dot, Clays) it was far and away the dirtiest. HOWEVER, I was trying to develop light bullseye loads and that was my problem. All powders will combust poorly if the pressures aren't high enough. The lower the pressure, the poorer the combustion and the more residue is left. The .45ACP is a low-pressure round to begin with, and loading it light is going to create issues. My experience is that Titegroup is particularly sensitive to this. Under "proper" pressures it actually burns quite cleanly (i.e. full power loads), but under low pressures it produced this thick gunk in the chamber that fouled the gun so much that it would no longer cycle after as few as 15-20 rounds. This was compared to say, W231, where under light loads it simply blew a lot of unburned powder out of the barrel and chamber, but didn't leave a lot of fouling.
So, if you are shooting "regular" loads Titegroup will be fine. It meters well and gives consistent results. If you want a powder for lighter loads, Hodgdon Clays (just Clays, not Universal Clays, not International Clays) is remarkably clean and is now my standard for bullseye (3.8 grains behind a 200 gr LSWC).