The differences are within how you do the load work up. It remains a test and retest option until you have satisfied your criteria.
A competitive F class shooter is vying to place as many shots into the V (1.2" at 300m, 2.5" at 500 and so on.) I use three shots at distance to confirm a node, then 5 shots or more to verify node and vertical at the distances you want to shoot at. Some rifles may show exceptional results at 300m but at 500 all hell breaks loose. So it pays to test your loads at varying distances. Just because you find a node you cannot stop there and must verify at your intended target distance.
Find a node by adjusting loads 0.5 grains(coarse method) then +/- 0.3 at say 200m for a 308 win. For a 223 you will need more fine tuning at 0.3 for coarse test and =/- 0.1 grains fine tuning.
Once you find a suitable node, adjust your load accordingly for distance shooting. Example. Your node lies at x at 200m testing. Test three loads +/- 0.2 grains of powder from your node for 308 or and 0.1 for 223 at 300m or more. You will see how vertical holds at distance that the shorter tests will not tell you. You will know you have hit the sweet spot when you can keep the shots within your specified criteria (ie 0.5 MOA at distance or better).
I am finding more often than not that the mid nodes perform better than the top nodes because they seem to behave better. I find more fliers using the top nodes so have been baking off on powder. Your loads will vary by season and temperature. Generally I have found the mid node to behave more for these seasonal changes than that very appealing top node. Oh yeah....be sure you are within 15 seconds of the shot when closing the bolt...the longer you have the cartridge in that hot barrel...the more wonky you will see the results. I would look hard at that 42.2 load as a node to test further.
My 2c.
So what is your method for finding said node. are you shooting 5 rnd groups at 200m? Then adjusting by .5 gr and shooting another 5 rnd group?