There have been articles in Home Shop Machinist about moving these critters. You have to be careful. A lathe on its stand or pedestals is really top heavy. If it starts to go, you aren't going to stop it.
With the proper equipment, and if the thing is readily accessible, it can be pretty straightforward. Proper equipment is the key. Jury rigged, improvised gear could result in the lathe being damaged, or someone getting badly hurt.
I bought an estate lot. Mill/drill on a serious base, Lincoln 220v welder, power hacksaw on a cabinet base, grinder on a cabinet, Atlas 7" shaper on a cabinet base. Borrowed a friend's trailer, and took a couple of friends with me. No problem getting the trailer loaded, there were more guys at the pickup location. Had to unload it, get everything into the shop and up and running by myself. I was excited to get the shaper. But have hardly used it. The grinder and power hacksaw, on the other hand have been very useful, and the mill/drill has been good to have.