Well you could reverse engineer to find out.I just question that nodes exist, I won't say they don't exist - the testing to prove that would be never ending
I pick a bullet I want to use, knock about 5% off the max load and load up ten rounds each with a few different powders (anywhere from 3 to 10 types). Seating depth will be at least .030 off lands, .050 off for monometals (or as long as mag lengths allow)
I'll fire the loads, in 3-5 round strings depending on barrel contour and intended use (hunting vs target) at 200 meters. Ending up with ten round group, which is measured for group size, mean radius. I will adjust the charge weight up or down, depending on what I am looking for. I'll retest the best results with 15 round groups, eventually what works the best will rise to the top
Take your good 10 round choice and compare it to a slightly different powder charge on either side. Shoot at 200 or farther. When I fine tune powder it’s only in one tenth steps.
Then you can also compare seating depth in the same way. I rough test in 3 thousand’s and fine tune in one thousand’s steps on either side.