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Your targets of coyotes to muskrats leaves a lot of play. Every rifle is different, so work a load up just like your manual says. (you do have one?) Your rifle will tell you what it likes. Good luck and small groups.
I have owned two 22.250. My current is a Remington VSSF II it likes 35.5 grns of IMR 4320 CCI 200 and 55 grn VMax or Nosler,s. It shoots one hole at 100 and I got 1.25 at 400 yds.
I also owned a Remington 788 it loved 36 grns IMR 4064 with a 52grn hollow point federal 210 primers and it would shoot 1/2 in all day, but as Iceman2 said each gun is different
Easy to load for the .22-250, but I've settled on TAC and a 52gr Horn HP for a do-all load. I like TAC because of how it meters, how efficient it is, and how it gives top-velocity performance using 50-55gr bullets.
52 grain Hornady Match HP's shoot amazing groups with of my sako 22-250. 34.5 or 35 grains of IMR4064. Not a super hot load but I have been shooting this combo since the early 1980's with no need to change.
55 grain bullets with a max load of IMR-8208 XBR makes a good accurate hunting load.
I have to say there hasnt' been a lot of inaccurate combinations for in this chambering. 4064 and 4320 works well too. The 8208 will probably be the all seasons load because of its temperature stability....I just havent' tested it in warmer temps yet.