A while ago there was that trend of putting a wad between the primer and powder. There are few who can honestly claim to have an improvement that is statistically significant. It's literally the last thing you need to worry about.
Are you patching to bore or groove diameter? I have no experience patching to groove, but quite a lot of experience patching to bore diameter.
First thing to think about is the chamber. Does your rifle have any sort of long freebore? y long I mean longer than 0.050". If so then consider patching to bore, or shooting grease grooved bullets. If not then bore diameter can work well for you. There are two main approaches. Lube cookie ( a thin wad, lube disc, and another thin wad ), or just an LDPE wad. Nearly any rifle will make decent groups with a lube cookie and you'll minimize risk of gas cutting and the leading that goes with it. But in terms of absolute accuracy, particularly at long range, you can make a single LDPE wad shoot a little better and with more consistent velocities.
The type of powder you use can make a big difference. Shooting bore diameter PP bullets is a fine balance between the right pressure curve to bump up the bullet, and too much pressure too quickly resulting in gas cutting. When you find the balance the results are good. Sometimes I use Swiss 1.5, Swiss Fg, or OE 1.5. I have loads that work well with one powder, but might shoot poorly if I change powder. They can be finicky. More so than grease grooved bullets.
For a number of years I was really into bore diameter PP bullets and ended up having a few different rifles built with Dan Theodore PP chambers. They shoot well, but I found that my long range scores were better with grease grooved bullets. PP bullets are still very interesting to me though, as all of the original American long range matches were shot that way so it's the most correct way to do it.
Oh one more thing. Plan to wipe between shots. For shooting PP bullets you want the bore absolutely clean and dry between shots for top accuracy. The best system I've used so far are Buffalo Arms bore wipers. I use two of them between shots, pushed by a dry patch. The bore comes out perfect between shots.
If you are looking for hunting accuracy, you can likely get by with a little undersized patched bullet, a lube cookie, and a blow tube.
Chris.