Varget is a fair bit too quick for a .25/06 with a 100-115 grain bullet. While there could certainly be safe, effective and accurate loads for Varget in this setup, its a bit of a mismatch, since you'll likely be giving up a good 200-300fps versus what you could get with a powder that would better fill the very large case volume that a .25/06 Improved offers (e.g. H1000, RL-25 class powders).