For the original question, I would use either the 140 TSX or the NP.
Re the smaller vs larger caliber arguement, I've shot a few moose and such, with cartridges ranging from a 25-06 and 115 NP's to a 358 Norma with 250 grain NorthForks. The quickest deadest moose? One shot with a 284 Winchester and 140 grain Nosler Partitions. The one shot with the Norma? It was a 2-point that ran 40 yards with a big hole through what used to be its lungs before it tipped over.
I agree with TB and 280_Ackley and the boys when it comes to general hunting. A good 140 grain bullet from a medium 7mm will kill as quickly in a hunting situation as my Norma.
That said, I DO live in grizzly country. It's tough to leave my 358 Norma and 225 TSX handloads clocking 2930 fps at home so I can carry my cute little 280Ackley and 140 grain handloads. More fun to carry, but when I'm stalking through a cutblock and see the fresh prints from mom and 2 large cub grizzlies, the Norma makes me feel MUCH more comfortable. That's why I own it. In a stopping situation , as opposed to a hunting situation, it wins.
A last thought...If I do decide to carry my 30-06, it will be with 168 grain TSX's at 2875 fps, NOT 220 grain cup and core bullets.