Ammo availability to me is a non-issue. I reload, I shoot some oddball archaic rounds that were obsolete 50 years ago - and I get on just finer n' frog's hair.
As for the ballistic turd polishing - it will matter to the paper punchers at longer ranges I suppose, but in the hunting/combat arena the choice really doesn't matter. With intermediate cartridges keep the ranges short, use a well constructed bullet - and good marksmanship will do the rest! In the real world where shots are under 300 and most are under half that, any differences between the rounds is purely conversational.