Supply and demand. I'm guessing budget is a concern. What I can tell you is some calibres are harder to find, and some are more popular. 30-30 is as common as dirt, and if you are patient and watch the EE you can get a nice rifle for I'd say between 250 and 400.00.(decent winnie 94 to nice 336)
I'd kinda like a 38-55, but not bad enough to pay what they're worth. I just closed a deal on a really nice .375win. "big bore"(94) for the wife instead.
To compare reloading costs, look up loads for each caliber. If I remember right, there's 5000gr of powder in a lb. that sells for around 32 bucks. Primers are neglegible, and jacketed leads cost between 25 bucks for 100 and 50 bucks for 50 for "general" leads. The bigger the diameter the bigger the price. Check the prices of the leads for the calibres you're considering.
If I remember right it costs between .25 and .28c/shot for my wife's 30-30, and up to about 1.70/shot for my 450(with htg bullets).
There's a saying in racing, "speed costs, how fast do you want to go?" Sorta same applies to shooting.
You've got the info from all the above answers that if you do your own research and calculations, you'll find what you want.
Let us know what you end up with and how you make out.