It depends on the circumstances. many of the old milsurp rifles that come into my hands need a lot of work, and sometimes can't hit a piece of paper past 25 yards. In which case its a good distance to get the rifles sighted and zeroed in before attempting my valuable home loads. For open sights I use a big piece of cardboard at 50 yards, and for scoped rifles I like to go a hundred. I like to know where every round goes when I'm running a batch of ladder loads. Why I suggest iron sights at 50 yards is because there is too much vision error when the front sight is wider than the target at 100 yards. When I'm testing ladder loads, I use only a 3 point shooting rest to remove any error of my own. Hand loads are valuable and take a lot of time to perfect. I insist on knowing without any doubt which load is a quarter of an inch better than the others. Otherwise, whats the point of looking for load accuracy when human error has been introduced to the mix.