Mixing powder

Yep. It's only when different powders get mixed that bad things can happen. Mind you, if you're loading match ammo you'll want the lots to be the same.
 
I do it, and I don't re work loads lot to lot either. Of course I only load mild to mid range cast bullet stuff, so I'm not exactly worried about over pressure conditions to begin with. Different if you're pushing the limits of sensibility, I expect
 
As long as you are mixing from two cans of the same product, I think the worst that may happen is if one has been open for long enough in conditions that degraded it you may have a variation in performance, but it might not even be noticeable.
 
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