I personally believe that the 243/6mm Cartridges are a bit light for animals the size of moose. Therefore, I would never take a 6mm Remington or a 243 specifically to hunt moose. That being said, I have shot two moose while packing a 6mm, but both were opportunistic situations. Both were easy broadside shots, neither were particularly large moose,[two-point bulls] and the load was a 100 grain Partition at around 3150 FPS. Neither moose moved after the shot, except to drop to the ground, dead. FWIW, both partitions were complete passthroughs, with exits the size of a quarter, but lungs like mush, so the 243/6mm pair will kill moose. I still feel there are so many better choices available that one should not use marginal chamberings for the job. Regards, Eagleye.