I have also used the 350 Speer on a few moose and had great results. Great penetration and the moose went down fast. I know another guy who has used the 350s on bison with the same results, both Speers and Hornady as well as some 350X bullets. This is also about my favorite round. I have used it on lots of game over the past 20 years with various bullets. It's never let me down. What is does in the Ruger #1 and #3 carbine is just amazing. In the levers also it is quite a cartridge. It's effects on game is something worth seeing. Match your bullets to the game of course. The 350 Speed was designed for .458 velocities and works well in heavy loads, the .405 Rem and 400 Speer were designed for the levers and slower velocities. The .350 Hornadys work well over a wide velocity range.