If muzzle brakes have a place, it's not on hunting rifles!!! Two of my pals have brakes on their rifles (.375 and .458) and claim to like them, but the fellow with the .375 nearly went deaf after he fired 2 rounds unprotected along the side of his house at a polar bear...he didn't hear the second shot. I don't know what the big deal about recoil is, if you can't handle it get a smaller gun. My test for a hunting rifle is to fire 3 shots prone, if I can't do it the guns is too much fort me. Thus far the .375 H&H, .375 Ultra, .416 Remington, .416 Rigby, and .458 Winchester has not been a problem, I can't say the same for the 7.62X54R Moisen Naigant - that thing pounded me.
Muzzle blast is bad enough without brakes, although I will grudgingly conceed that custom brakes maybe somewhat less damaging than factory ones. The worst I've experienced is standing directly behind a .30-378 Weatherby, and my pal's .375 is second.
Even without brakes, shooting close to a barrier or into the wind can increase the discomfort from muzzle blast.