More factory rifles in AI than standard 280 from what I've seen. Savage lists 8 products in 280ai, none in 280. Browning lists 7 AIs, 6 Regular 280s, but most of those regular ones are listed as discontinued whereas the 280ai's are not. Interestingly, the 280AI is not available in the more basic Xbolts, only more fancy Xbolt options - pro, speed, Hells canyon, etc, whereas the 280 rem is available in the Xbolt Hunter and Medallion. Neither are available in the composite stalker these days.
And ammo is similar but opposite - there is options for both, but the regular one seems to have more options (based on looking at Federal, Hornady, Winchester, and Remington).
But unless you handload I feel like 7mm Rem Mag is a better option. Or even 7mm08 if the Rem Mag is too much gun.