Don't understand why is there such a tendency to overthink this stuff. One load that will do everything out to 300 yards in a hunting rifle is not hard to accomplish. ALL of my most-used outfits are set up for that, and it doesn't matter if I come upon a grizzly while hunting caribou, a wolf while after sheep, or a huge bull moose while stalking a black bear. Regardless of what I have in my hands at the time, I know the trajectory of the bullet and the anatomy of the animal well enough to determine the shot out to that range. I am never thinking about what bullet or load I am using. Doesn't matter if it's my old 270 Winchester or my 9.3X62, I KNOW what I am using.
It makes things a lot simpler.
The only exception here, is that for woods bison, which often exceed well over 2000 pounds live weight, there is a minimum caliber and energy requirement to hunt them legally. Of course, that means that anything you might encounter while hunting bison will be easily dispatched with the rifle and load you might be carrying at that time.
And, I do check the zero with a couple of shots at the range before every Spring and Fall hunting season.
Ted