I used mostly H1000 in mine for about 600 rounds , which is about where the groups went to crap. It sucks when a rifle gets sick. Anyway, since my 1/2 MOA custom Sako turned into a 2 MOA noisemaker I decided to see if Nosler knew anything when they commented on benchrest type accuracy with IMR 4350 and 180s. Nothing to lose but a bit of powder and bullets, before banishing the rifle to the rebarrelling rack. I'm used to rifles that eat barrels, but 600 was pushing it even for me.
Long story made shorter, the starting loads in the Nosler book (This rifle never gets to the max charges or even the middle with anything, short throat) gave me my rifle back and still does 3250 fps. It is easy to get along with, being so mild to shoot that I wouldn't have believed the chronograph if the 800 yard drops didn't confirm it. Interestingly the muzzle blast and concussion no longer makes my think someone hit me across the shoulder blades with a fence post on every shot.
I've heard and read, and probably repeated how cases should be full for accuracy but I can sure think of a lot of full case loads that didn't shoot and a lot of not so full cases that do. For speed I've found the order that they are listed in the manual in their rifle may not be the same in mine.
I wouldn't rule out your faster burning powders out of hand, though I'd start with Retumbo.