USP all the way. I have 4 of them...a 9mm, .40S&W, and two .45's (full size and tactical)...don't regret spending a single penny on either one of them. They may be a little thicker or bulkier than other pistols of the same caliber, but they are built well and are very accurate. I don't have very big hands, but I find that the USP series, when compared to other brands, especially in .45 Auto, are alot easier to hold/grip. Don't know if it's because I've become accustomed to my USPs, but they just feel more comfortable than some other pistols.