it will depend on the strength and the details of your prescription. Mine is too strong and/or too weird to work with ANY insert-based system I've seem, tried, or found on the internet. In the end, I just ended up going to lenscrafter's and buying regular, prescription safety glasses, with plastic side shields. They don't look glamorous at all, but they work just great - huge field of vision, thick lenses provide full protection, and are comfy. do they look geeky? Sure, but I don't care, I only wear them on the range (YMMV).
So, if you can find custom frames with inserts which work 100% for you, good on you, go for it. If not, know that you can get just regular safety glasses, and they will work just fine for you too.