I perhaps make it un-neccessarily complicated - my last "store made" rifle was a Ruger Compact (16.5" barrel) in 243 Win, with a 2-7x33 Leupold scope. I thought it was about the perfect "old guy's" combination, for what I do. Now I have a 24" 257 Robert's barrel on order for a Mauser 98 - so that too was touted as the ideal "varmint + deer" combination. My intention is 95 grain Partition in the little 243 Win and 115 Partition or 117 grain Interlock in the 257 Roberts - whichever I can find a good load for. Just do not see self using either for varmints - I would most likely take the 223 Rem or a 22-250 with 50 or 55 grain V-Max or B-Tip - whichever that I have on hand. Actually, next time in gopher patch will likely be with an aperture sighted 9.3x57 and 285 grain cast bullets - just because.
I do load .243" 55 grain V-Max with start load of Hunter powder for my grandson to use in his 243 Win - seems to scare hell out of gophers and various varmints on the other Grandpa's farm, I am told. More importantly, gives him a chance to practice handling larger cartridges than .22 rimfire - loading magazine, etc. - where do you stow spare rounds, or spare magazine - does it do you any good in a hurry? - and to learn to pass up shots that he knows he can not make or that has the farm dog is down range - all realistic "hunting" stuff that he does not normally get at a shooting table at a range.