The 30-06 is quite Catholic in it's powder choices. Many powders work well. Obviously one of the 4350's will be good, but I have had good success also with H414, W760, RL19, RL22, IMR4831, Vihtavuori N160,N550,N560, Norma 204 and MRP, H4831SC with bullets from 165-220 grains. For the lighter bullets H/IMR4895, IMR4320, IMR4064, RL15, Vihtavuori N140,N150, H380, W748, Varget all work well. My all time favorite varmint load in the '06 is a 125 Ballistic Tip and a big charge of H4895.....impressive performance! In big bear territory, the 200 Partition and 58 grains of Norma MRP gets the nod. The '06 will do the job, big or small. Regards, Eagleye.