If there is a severe ring, then the pressure MIGHT end up being a bit high for a 45 Colt. But since the 454 Casul runs at 50,000 psi, an itty bitty ring of wax/lead, isn't going to stop it. Peak pressure for a 454 is after about 3/4 inch of bullet travel, so it will be way past the ring at peak pressure.
Also, if the buildup is that severe, you probably won't even be able to chamber the 454 round.