I just did some trigger work on my S&W 625 (.45 ACP) and wanted to check that a slightly reduced trigger spring weight would still detonate the primers consistently. So I loaded up a moon clip full of brass with primers only and fired them in my basement. After the first round the cylinder locked up. When I finally got the cylinder free I saw that the fired primer had backed out a little. As this happened consistently, I take it that this may be "normal" but I can't see why. No doubt there is a simple explanation...
Stuart