One suggestion - 35 Whelen!!!! I've looked up and down, long and hard at the 338-06... numerous times, and just can't warm up to it (believe me, I have thought about building one a few times...been very close even recently). However, every time I sit down with a ballistics program, it offers no noticable trajectory gain.... with less frontal area that the 35 Whelen.
Sure the SD's are higher for 225 vs 225 etc... but I've only recovered 1 bullet from a critter thus far from my Whelen (225 gr TSX lengthwise down the spinal column of a whitetail (after breaking the pelvis and 2'+ of spine), and 250gr Speers have been unstoppable.
As for "close enough to 35 Cal".. sure it is, but there is less difference between 35 Cal and 375 Cal than there is between the 338 Cal and 35 Cal.... food for thought.
2725fps w/225gr bullets
2550 fps w/250gr bullets
Will a critter know the difference between the 338-06 and the 35 Whelen? Likely not... but the "Thwack" a 250gr 35 cal bullet makes brings a twisted smile to my face (grin)!
280_ACKLEY