Powder measures are sensitive to the technique of the user. I do my best to ensure that each throw is made uniformly and I keep the powder column topped up. If the powder measure is jarred between throws, it may cause the powder to settle, affecting it's loading density in the hopper, thus changing the amount of powder measured on a subsequent throw.
The type of powder you attempt to throw plays a role in the uniformity of each throw. Ball powders typically produce the best uniformity of thrown charges, so you should be in good shape with Titegroup. Short extruded powders are next best in uniformity, then extruded. Flake powders are the worst to use in a powder measure since each flake is so light, they are the most likely to hang up, often under-loading one charge, then overloading the next. When flake powders are used, a cheap set of Lee spoons provides better uniformity than a powder measure.