You should get the type of accuracy you and your rifle are capable of.
Here is what I have done over a long period of time, when trying out a new to me rifle. 99.999% chance it will handle just fine, the "maximum" load shown in any reputable modern loading book. So use your own judgement on how you ascertain that a "maximum" load is safe to shoot in your rifle.
Of the powders mentioned, 760, which is said to be the same as H414, is the powder I would use, as I have found H414 to be the best in both velocity and accuracy on the 243, with Varget next.
Load five rounds of what is shown at "maximum" with the powder and bullet chosen, I would use the 80 grain, get the best rest you can get, where you feel the most comfortable and fire the five rounds one after the other, so the barrel heats up during shooting.
If you felt you shot a very good group, but it actually is 2 inches or more, or it shows a definite walking pattern, do not load another round until you have had your rifle and barrel properly bedded.
If the group is around one inch, either on first trial or after bedding, there is a about a 95%, maybe better chance, that it will shoot its beat accuracy at full load and piddling around with near trace amounts of varying powder charges will mean no change in accuracy that you can determine, or duplicate the next time. So just load up full loads and shoot away.