I've shot 45 - 70 with cast bullets for 25 yrs or so, and my best load has been 24 - 25 gr of 2400 behind a 425gr pointed mould made by saeco. Using 20 : 1 lead and tin, I frequently get groups under 1" for 5 shots @ 100yds. That's shooting a rolling block with good aperature sights and a 34" Bauska barrel. I've tried a number of other powders, but none have been as good in my rifle. 4895 consistently hung fire and shot very poorly, although some of my friends do well with it. There seems to be a lot of difference from 1 rifle to another. Good luck with yours.