I've been trying quite a few different powders, with bullet weights from 130 to 145 grains in one of the twins, the one marked 7-08.
IMR4350 is sure a go to powder, except for the high compression. I've gone to 50 grains, but that fills the case to the top of the neck! Using the long, 140 grain semi boat tail Nosler ballistic tip on top of that, and considering the bullet has to be seated deep to work through my magazine, you wonder if it can compress that much, without pushing the bullet back up. But it works, and shoots very good, as high a velocity as can be expected and very accurate. The same charge of Norma 204 only comes up to about half way on the neck, will give equal, or a hair better, velocity and at least as accurate. Of course, the downer to Norma powder is you just can't trot to your local sporting goods store and get it.
If I had to choose one powder, of the ones I have tested, for the 7-08 with the bullet weights mentioned, it would be H414. Hodgdon on line shows 47 grains of H414, 130 grain bullet at 2925 fps. For me, that load gave 2848 fps, which is much closer to what the loading chart showed, than any other powder I tried. I use standard Federal primers and didn't find H414 any dirtier than any other powder.
I have also settled on H414 as being the best powder in the 243, at least with bullets in the 70-75 grain class. It has been very accurate in both calibres.
Back to the 7-08, I just couldn't get the velocity up with either 3031 or 4320 powder.
The two powders I was most disappointed in were Superformance and Reloader 15. I found an on line reloading chart that showed 41.2 grains of RL15 with a 130 grain bullet to give 2900 and 42.6 grains to give 3,000 fps. For me, 42.6 grains averaged 2694, a far cry from the 3,000 fps shown in the loading chart!
I am using a Tikka T3 Lite, with 22 inch barrel. Accuracy was excellent, with every full up load tried. If I used a very good rest and felt good while shooting, the group would go to under 1 MOA. No groups were much worse and all groups came surprisingly close to the same poi. It's a pleasure working with a rifle like that.