The .375 is a do all caliber, and the Ruger #1 is a handy and handsome rifle - one of my favorites. Make sure your ammo chambers easily before you go hunting though as the #1` doesn't have much camming power, and you don't want to be fighting to close the action if you need a second shot. The Barnes TSX is so good I'm not sure why anyone would want to use anything else, but if you anticipate long shots the Sierra should hold together. I think premiums are at their best when ranges are short and velocities are high.