I shoot DA as SA almost all the time due to the trigger pull. As far as this gun the two rounds will fire different and hit different point of aim, point of impact. Also if shooting say .45ACP almost all the time than the cylinder would foul up and have to be cleaned before .45Colt would be inserted. Personally I think Ruger has a few quality control issues lately as well to be watched out for. In theory it is a great idea, in practice not as great but alright. You should plan to shoot one of these rounds mostly and set the gun up for that. If you go for moon clips get the tool to load and unload the moon clips. Or make one, hard to do it by hand and the tool makes it much easier.