For a do "everything rifle" that might meet a buffalo someday a .375 is hard to beat. I've shot animals ranging from steinbuck on the small end to giraffe as the heaviest. In between there's a pile of deer and elk sized game and 10 buffalo. In a pinch you could do it all with a single bullet choice, then add a solid load and take elephant too. With recoil that is approximately double that of a 30-06 and a similar trajectory it is quite do-able.
Now to switch gears a bit, if you wanted a "buffalo gun" that can take care of most everything else I wouldn't completely rule out the .458. You have to make some allowances, recoil that can be close to double that of the .375 is hard to ignore and handloading is necessary. My 450 grain loads have accounted for 9 buffalo so far. Sighted in 2 inches high at 100 they print 3 inches low at 200 yards, while still only being 1 inch high at 50 and dead on at 25. The darn elephant gun is a little more versatile than you might think. You can easily sight a little higher for general purpose hunting and stretch things out a bit. Handloaded 300 and 350 grain Barnes TSXs change things even more. A 300 grain chunk of copper at 2800 fps is a completely different critter than a 500 grain factory load that may not even break 2000.
Now to switch gears a bit, if you wanted a "buffalo gun" that can take care of most everything else I wouldn't completely rule out the .458. You have to make some allowances, recoil that can be close to double that of the .375 is hard to ignore and handloading is necessary. My 450 grain loads have accounted for 9 buffalo so far. Sighted in 2 inches high at 100 they print 3 inches low at 200 yards, while still only being 1 inch high at 50 and dead on at 25. The darn elephant gun is a little more versatile than you might think. You can easily sight a little higher for general purpose hunting and stretch things out a bit. Handloaded 300 and 350 grain Barnes TSXs change things even more. A 300 grain chunk of copper at 2800 fps is a completely different critter than a 500 grain factory load that may not even break 2000.






















































