If I can't get a keg of 8lbs, I will buy as much powder of one type as I can. I won't even look at the lot numbers. I just take all of it and mix it together.
This may sound ridiculous but I have found that the only powder that doesn't seem to blend consistently is IMR 4320. Everything else, seems to just level out. When I try a new batch, I will usually reduce the test loads by as much as 5%. I load 5 test rounds then if all looks well, go to the base load, recorded for accuracy.
As Ganderite mentioned, some powders have huge swings in burn rate from lot to lot. That is why it is such a pain when you're buying a pound at a time. I feel sorry for the guys that pick up half cans and less at gun shows, because that's all they can afford. Hardly worth the effort if you are an accuracy nut.
Even if that's all you can afford, mix the lots into as large a batch as you can put together. You will be surprised at how consistent your mixed batches will be.
One of the biggest problems with powder today, is you don't know what plant it was made in or even which country. Any given lot of powder, can be made anywhere from Sweden to Russia, to France to Pakistan to China etc. There will be differences between all of these.
Learn to blend powders of the same burn rate and mark. Gets rid of the roller coaster effect.
I've seen guys completely dumbfounded when their pet loads in their fly chaser all of a sudden goes awry. More often than not, it can be blamed on a new can of powder or a new batch of bullets. Bullets are so consistent today that there is little or no variation between lots.